|
KMID : 0191120000150010088
|
|
Journal of Korean Medical Science
2000 Volume.15 No. 1 p.88 ~ p.92
|
|
|
Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium
|
|
Lee YH
Choi SJ/Kim A/Kim CH/Ji JD/Song GG
|
|
|
Abstract
|
|
|
The aim of this study was to investigate the expression and localization of cyclooxygenase-1
and -2 (COX-1 and COX-2) in synovial tissues from patients with rheumatoid arthritis (RA).
Synovial tissues from 9 patients with RA and 5 patients with osteoarthritis (OA) were examined
for COX-1 and COX-2 expressions by immunohistochemical staining using 2 polydonal COX-1 and
COX-2 antibodies. In RA synovia, synovial lining cells showed intense immunostaining for
COX-1, whereas slight to moderate staining was observed in inflammatory cells, stromal
fibroblast-like cells and vascular endothelial cells. There was no significant difference
in COX-1 expression between RA and OA synovia. The localization of COX-2 expression dearly
differed from that of COX-1 expression, being most intense in inflammatory cells. However,
there was no difference in COX-1 and COX-2 expressions between RA and OA synovial tissues.
Our observations support that inflammatory mechanisms modulated by COX-1 and COX-2 in chronic
RA synovium might be similar to those in chronic OA synovium.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|